To sterilise something is to kill every germ on it, so that nothing living is left. You sterilise a baby's bottles in boiling water, and the dentist sterilises the instruments before the next patient sits down.
It is stronger than clean and stronger than disinfect: disinfecting cuts the germs down, sterilising gets rid of all of them, which is why hospitals use steam under pressure rather than a wipe. The adjective is sterile — a sterile dressing, a sterile room. Said of an animal or a person, sterilise means something else entirely: to operate so that they cannot have young, which is what happens to a cat at the vet's. American English spells it sterilize.
1verbsteriliseTo make something completely free of germs.
“Sterilise the jars in a hot oven before you fill them with jam.”
2verbbreedTo make a person or an animal unable to have young, by an operation.
“The shelter sterilises every cat before it goes to a new home.”
Also accepted in games: sterilize
Practised in Cleaning & Housework, Babies & Growing Up