Upstate means in or towards the northern part of a state. Live upstate, drive upstate, upstate New York.
It is American and belongs above all to New York, where upstate means everything that is not the city — which is most of the state and is a cultural division as much as a geographic one. There is no downstate in most people's speech, though the word exists.
1adverbupstateIn or towards the northern part of a state.
“Every summer we drive upstate to my grandparents' cabin by the lake.”
upstate is a direction.
From up + state.
Etymology from Wiktionary, CC BY-SA